Endocrine Abstracts

Introduction: Carcinoid crisis, as an entity is poorly defined, but can be seen in patients with small bowel NET tumours after open bowel surgery or tumour unrelated procedures as cardiovascular instability (CI). Recent evidence suggests that cardiovascular instability (CI) during NET surgery is more common than previously considered.Aims and methods: We audited the incidence of CI during procedures and determined the relationship to perioperative octreo...

Introduction: There remains controversy about which patients benefit from removal of their primary small bowel tumour and whether this should be performed in a specialist tertiary referral hospital as an elective procedure. Part of the decision making and consenting process in patients with metastases will be a shared decision about surgery with the patient in light of symptoms, morbidity from surgery and survival. The aim of this study was to elucidate important institution s...

PGC1 and RIP140 are key regulators of nuclear receptor signalling that control metabolic gene expression in adipose tissue, liver and muscle. PGC1 promotes whereas RIP140 represses the expression of a network of catabolic genes in adipose and muscle. Thus mice devoid of RIP140 accumulate less fat in adipose tissue and liver while mitochondrial biogenesis and respiration is increased in type 2 muscle fibres; as a consequence, the mice maintain their insulin sensitivity as they ...